(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Base Information

Chemical Name:(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid
CAS No.:1445983-29-8
Molecular Formula:C₂₇H₃₁Cl₂N₃O₃S
Molecular Weight:548.533
Hs Code.:

Synonyms:(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Suppliers and Price of (R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

There total 19 articles about (R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445985-59-0
(R)-methyl 5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoate

: 1445983-29-8
(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; for 6h;

Reference yield:

: 1984-58-3
2,5-dichloroanisole

: 1445983-29-8
(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: titanium tetrachloride / dichloromethane / 2 h / 0 - 60 °C

2: lithium chloride / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide

5: hydrogen; rhodium contaminated with carbon / ethyl acetate

6: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C

7: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 °C

8: potassium carbonate / N,N-dimethyl-formamide / 60 °C

9: lithium hydroxide monohydrate; water / tetrahydrofuran / 6 h

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; lithium hydroxide monohydrate; rhodium contaminated with carbon; water; hydrogen; titanium tetrachloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 4: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 381229-74-9
4-methoxy-3,6-dichlorobenzaldehyde

: 1445983-29-8
(R)-5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: lithium chloride / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide

4: hydrogen; rhodium contaminated with carbon / ethyl acetate

5: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C

6: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 °C

7: potassium carbonate / N,N-dimethyl-formamide / 60 °C

8: lithium hydroxide monohydrate; water / tetrahydrofuran / 6 h

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; lithium hydroxide monohydrate; rhodium contaminated with carbon; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308