(Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene

Base Information

• Chemical Name: (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene
• CAS No.: 1380439-42-8
• Molecular Formula: C₁₅H₁₃Cl
• Molecular Weight: 228.721
• Mol file: 1380439-42-8.mol

Synonyms:(Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene

Chemical Property of (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene

There total 8 articles about (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + p-chloroacetophenone tosylhydrazone (75230-50-1) → (Ε)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (58662-11-6) + (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (1380439-42-8)

Guidance literature:

With copper(l) iodide; triphenylphosphine; lithium tert-butoxide; In toluene; at 90 ℃; for 10h; Overall yield = 57 %; Overall yield = 65 mg; diastereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0034-1378231

Reference yield:

(1-(4-chlorophenyl)ethyl)tripropylphosphonium bromide + benzaldehyde (100-52-7) → (Ε)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (58662-11-6) + (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (1380439-42-8)

Guidance literature:

With lithium hydroxide; In water; at 100 ℃; Overall yield = 93 %; Sealed tube;

DOI:10.1016/j.bmcl.2019.03.033

Reference yield:

bromochlorobenzene (106-39-8) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (Ε)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (58662-11-6) + (Z)-1-chloro-4-(1-phenylprop-1-en-2-yl)benzene (1380439-42-8)

Guidance literature:

With [Pd{1-[2′-(methoxycarbonyl)phenyl]-3-[4′-bromophenyl]triazenide}]₂; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 4h; Overall yield = 43 %; Catalytic behavior; Schlenk technique; Sealed tube;

DOI:10.1016/j.ica.2019.03.004

upstream raw materials:

2-(p-Chlorphenyl)-2-hydroxy-1-phenylpropan

para-chloroacetophenone

benzaldehyde

p-chloroacetophenone tosylhydrazone