2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

Base Information

Chemical Name:2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide
CAS No.:872984-03-7
Molecular Formula:C₃₆H₄₆N₄O₃SSi
Molecular Weight:642.938
Hs Code.:

2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

Synonyms:2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

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Chemical Property of 2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

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Technology Process of 2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

There total 8 articles about 2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 872983-49-8
[(1S)-1-{1-benzylcarbamoyl-1-[2-(tert-butyldiphenylsiloxy)ethyl]butylcarbamoyl}-2-(thiazol-4-yl)ethyl]carbamic acid tert-butyl ester

: 872984-03-7
2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 872983-37-4
2-amino-2-(2-hydroxy-ethyl)-pent-4-enoic acid

: 872984-03-7
2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd-C / methanol / 14 h / 20 °C

2: 2.4 g / hydrochloric acid / 16 h / Heating

3: 97 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

4: lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

5: 1.61 g / imidazole / CH₂Cl₂ / 0 °C

6: 1.45 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

7: 26 percent / trifluoroacetic acid / CH₂Cl₂ / 0 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: C₁₆H₂₈NO₄S⁽¹⁺⁾*BF₄^(1-)

: 872984-03-7
2-(2-amino-3-thiazol-4-yl-propionylamino)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pentanoic acid benzylamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / 16 h / Heating

2: H₂ / Pd-C / methanol / 14 h / 20 °C

3: 2.4 g / hydrochloric acid / 16 h / Heating

4: 97 percent / 2-phenylbenzoxazole; ethyldiisopropylamine / CH₂Cl₂ / 0 °C

5: lithium hydroxide / tetrahydrofuran; H₂O / 0 °C

6: 1.61 g / imidazole / CH₂Cl₂ / 0 °C

7: 1.45 g / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / 0 °C

8: 26 percent / trifluoroacetic acid / CH₂Cl₂ / 0 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide; sodium hydroxide; 2-phenylbenzo[d]oxazole; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019