4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate

Base Information

• Chemical Name: 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate
• CAS No.: 1465783-87-2
• Molecular Formula: C₇H₈O₃S*C₃₂H₃₈N₄O₄S
• Molecular Weight: 764.85

Synonyms:4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate

Chemical Property of 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate

Chemical Property:

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Safty Information:

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Technology Process of 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate

There total 6 articles about 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[4-methylpiperazine-1-carbonyl]amino-3-[14C6]phenyl[14C3]propionic acid (1465783-85-0) + toluene-4-sulfonic acid (104-15-4) + 3-benzenesulfonyl-1-phenethylallylamine tosylate → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrotosylate (1465783-87-2)

Guidance literature:

(S)-2-[4-methylpiperazine-1-carbonyl]amino-3-[14C₆]phenyl[14C₃]propionic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 - 0 ℃; for 2h; Inert atmosphere;

3-benzenesulfonyl-1-phenethylallylamine tosylate; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at -30 - -15 ℃; for 2h; Inert atmosphere;

toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/jlcr.3107

Reference yield:

benzyl (S)-[4-methylpiperazin-1-carbonyl]amino-3-[14C6]phenyl[14C3]propionate (1465783-84-9) → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrotosylate (1465783-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Pd/C (30%); hydrogen / ethanol / 16 h / 760.05 Torr

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere

2.2: 2 h / -30 - -15 °C / Inert atmosphere

2.3: 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; Pd/C (30%); hydrogen; isobutyl chloroformate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/jlcr.3107

Reference yield:

C(14)C9H9NO3 → 4-methyl-N-((S)-1-oxo-3-[14C6]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C3]propan-2-yl)piperazine-1-carboxamide hydrotosylate (1465783-87-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 72 h / 0 - 20 °C / Inert atmosphere

2.1: pyridine / toluene; dichloromethane / -40 °C / Inert atmosphere

3.1: tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

4.1: Pd/C (30%); hydrogen / ethanol / 16 h / 760.05 Torr

5.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere

5.2: 2 h / -30 - -15 °C / Inert atmosphere

5.3: 16 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; hydrogenchloride; Pd/C (30%); hydrogen; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/jlcr.3107

upstream raw materials:

benzyl (S)-[4-methylpiperazin-1-carbonyl]amino-3-[14C₆]phenyl[14C₃]propionate

(S)-2-[4-methylpiperazine-1-carbonyl]amino-3-[14C₆]phenyl[14C₃]propionic acid

toluene-4-sulfonic acid

[14C(U)]-(L)-phenylalanine benzyl ester hydrochloride

Downstream raw materials:

4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride

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