1465783-84-9

Upstream product

• 1465783-81-6 [14C(U)]-(L)-phenylalanine benzyl ester hydrochloride 
• 109-01-3 1-methyl-piperazine 
• 1465783-82-7 benzyl (S)-2-isocyanato-3-[14C₆]phenyl[14C₃]propionate 

Downstream Products

• 1465783-85-0 (S)-2-[4-methylpiperazine-1-carbonyl]amino-3-[14C₆]phenyl[14C₃]propionic acid 
• 1465783-87-2 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrotosylate 
• 1465783-89-4 4-methyl-N-((S)-1-oxo-3-[14C₆]phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)-[14C₃]propan-2-yl)piperazine-1-carboxamide hydrochloride 

Relevant academic research and scientific papers

Carbon-14 labeling of K777·HCl, a therapeutic agent for Chagas disease

The antitrypanosomal agent K777·HCl was labeled with carbon-14 to support absorption, distribution, metabolism, and excretion studies of this potential new drug for the treatment of Chagas disease. The radiolabeled compound was prepared in eight steps from [14C(U)]-(L)-phenylalanine with a specific activity of 54.4 mCi/mmol and an overall radiochemical yield of 4.1%. Copyright