C₂₅H₄₀LiNO

Base Information

• Chemical Name: C₂₅H₄₀LiNO
• CAS No.: 79288-69-0
• Molecular Formula: C₂₅H₄₀LiNO
• Molecular Weight: 377.54
• Mol file: 79288-69-0.mol

Synonyms:C₂₅H₄₀LiNO

Chemical Property of C₂₅H₄₀LiNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₅H₄₀LiNO

There total 1 articles about C₂₅H₄₀LiNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-tert-butyl-2,4,6-triisopropylbenzopiperidide (79288-68-9) → C25H40LiNO (79288-69-0)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo00333a049

Reference yield: 49.0%

C25H40LiNO (79288-69-0) + benzaldehyde (100-52-7) → [(2R,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-piperidin-1-yl]-(2,4,6-triisopropyl-phenyl)-methanone (79288-70-3)

Guidance literature:

DOI:10.1021/jo00333a049

Reference yield:

C25H40LiNO (79288-69-0) → [(2S,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-piperidin-1-yl]-(2,4,6-triisopropyl-phenyl)-methanone (79288-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent

2: 1.) Pyridinium Chloroformate, 2.) NaOMe, 3.) LiAlH₄

With lithium aluminium tetrahydride; pyridinium chloroformate; sodium methylate;

DOI:10.1021/jo00333a049

upstream raw materials:

4-tert-butyl-2,4,6-triisopropylbenzopiperidide

Downstream raw materials:

[(2R,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-piperidin-1-yl]-(2,4,6-triisopropyl-phenyl)-methanone

[(2S,4S)-4-tert-Butyl-2-(hydroxy-phenyl-methyl)-piperidin-1-yl]-(2,4,6-triisopropyl-phenyl)-methanone