(+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

Base Information

Chemical Name:(+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea
CAS No.:1256930-19-4
Molecular Formula:C₂₅H₂₃N₃O₂
Molecular Weight:397.477
Hs Code.:

Synonyms:(+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

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Chemical Property of (+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

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Technology Process of (+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

There total 2 articles about (+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1256930-07-0
1-(4-cyano-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

: 1256930-19-4
(+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: 1-(4-cyano-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol102155h

Reference yield:

: 1256930-35-4
(R)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

: 1256930-19-4
(+/-)-1-[1-(4-cyanophenyl)-1-phenylallyl]-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: 3 h / Inert atmosphere

2.3: Inert atmosphere

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/c2cc38704b