N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

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Chemical Name:N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide
CAS No.:1267688-15-2
Molecular Formula:C₂₁H₁₅ClF₆N₄O
Molecular Weight:488.82
Hs Code.:

Synonyms:N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

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Chemical Property of N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

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Technology Process of N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

There total 4 articles about N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: (1R)-N₂-{6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}-1-phenylethane-1,2-diamine hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 1267688-15-2
N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 847756-88-1
(3-chloro-4-(trifluoromethyl)phenyl)boronic acid

: 1267688-15-2
N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / triphenylphosphine; palladium diacetate / acetonitrile; water / 2 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; diethyl ether / 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; sodium hydrogencarbonate; triethylamine; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; acetonitrile;

Reference yield:

: 1267687-88-6
tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

: 1267688-15-2
N-[(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; diethyl ether / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;