tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

Base Information

Chemical Name:tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate
CAS No.:1267687-88-6
Molecular Formula:C₂₄H₂₄ClF₃N₄O₂
Molecular Weight:492.928
Hs Code.:

Synonyms:tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

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Chemical Property of tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

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Technology Process of tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

There total 2 articles about tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 188875-37-8
((R)-2-Amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 954223-40-6
4-chloro-6-(3-chloro-4-trifluoromethylphenyl)-pyrimidine

: 1267687-88-6
tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 847756-88-1
(3-chloro-4-(trifluoromethyl)phenyl)boronic acid

: 1267687-88-6
tert-butyl [(1R)-2-({6-[3-chloro-4-(trifluoromethyl)phenyl]pyrimidin-4-yl}amino)-1-phenylethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / triphenylphosphine; palladium diacetate / acetonitrile; water / 2 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With potassium phosphate; sodium hydrogencarbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; acetonitrile;