3'-methoxy-4'-methylsulfonyloxypropiophenone

Base Information

• Chemical Name: 3'-methoxy-4'-methylsulfonyloxypropiophenone
• CAS No.: 203383-29-3
• Molecular Formula: C₁₁H₁₄O₅S
• Molecular Weight: 258.295
• Mol file: 203383-29-3.mol

Synonyms:3'-methoxy-4'-methylsulfonyloxypropiophenone

Chemical Property of 3'-methoxy-4'-methylsulfonyloxypropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3'-methoxy-4'-methylsulfonyloxypropiophenone

There total 1 articles about 3'-methoxy-4'-methylsulfonyloxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methanesulfonyloxy-3-methoxybenzaldehyde (52200-05-2) → 3'-methoxy-4'-methylsulfonyloxypropiophenone (203383-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 28 h / -78 - -35 °C

2: 14.7 g / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 0.33 h / -55 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1: Grignard reaction / 2: Swern oxidation;

DOI:10.1246/bcsj.71.475

Reference yield: 96.0%

3'-methoxy-4'-methylsulfonyloxypropiophenone (203383-29-3) → 2-bromo-3'-methoxy-4'-methylsulfonyloxypropiophenone (203383-30-6)

Guidance literature:

With hydrogen bromide; bromine; In dichloromethane; acetic acid; for 0.5h;

DOI:10.1246/bcsj.71.475

Reference yield:

3'-methoxy-4'-methylsulfonyloxypropiophenone (203383-29-3) → 4,4'-(3,4-dimethylfuran-2,5-diyl)bis(2-methoxyphenol) (10035-27-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / hydrogen bromide; bromine / CH₂Cl₂; acetic acid / 0.5 h

2: 55 percent / [ReCl(N₂)(PMe₂Ph)4] / dimethylformamide / 0.67 h / Heating

3: 81 percent / methyllithium / tetrahydrofuran; diethyl ether / 0 - 20 °C

With hydrogen bromide; methyllithium; bromine; [ReCl(N₂)(PMe₂Ph)4]; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Bromination / 2: Cyclization / 3: deprotection;

DOI:10.1246/bcsj.71.475

upstream raw materials:

4-methanesulfonyloxy-3-methoxybenzaldehyde

Downstream raw materials:

2-bromo-3'-methoxy-4'-methylsulfonyloxypropiophenone

4,4'-(3,4-dimethylfuran-2,5-diyl)bis(2-methoxyphenol)

2-methoxy-4-(1-methoxy-1-propenyl)-1-methylsulfonyloxybenzene

2,5-bis(3-methoxy-4-methylsulfonyloxyphenyl)-3,4-dimethylfuran