[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Base Information

Chemical Name:[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran
CAS No.:527742-75-2
Molecular Formula:C₁₈H₂₆O₄S
Molecular Weight:338.468
Hs Code.:

Synonyms:[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Suppliers and Price of [2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

There total 16 articles about [2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 385809-11-0
[3R,5S]-[5-(1R,S)-(1-ethoxyallyloxy)-3-methyl-oct-7-ene-1-yl-sulfonyl]benzene

: 527742-75-2
[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: [3R,5S]-[5-(1R,S)-(1-ethoxyallyloxy)-3-methyl-oct-7-ene-1-yl-sulfonyl]benzene; With Grubbs catalyst first generation; In dichloromethane; for 2h; Heating;

With pyridinium p-toluenesulfonate; In ethanol; at 20 ℃; for 16h;
DOI:10.1021/jo026743f

Reference yield:

: 41976-28-7
(5S,6R)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-one

: 527742-75-2
[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 13 steps

1.1: 95 percent / Zn powder; Cu(OAc)2*H₂O / acetic acid / 24 h / 80 - 90 °C

2.1: 87 percent / DBU / tetrahydrofuran / 20 °C

3.1: 96 percent / 2N HCl / 16 h / 20 °C

4.1: 89 percent / imidazole; DMAP / CH₂Cl₂; toluene / 16 h / 0 - 20 °C

5.1: CuI / 0 °C

5.2: 84 percent / diethyl ether / 1 h / 0 °C

6.1: 98 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

7.1: 83 percent / Bu₃P / tetrahydrofuran / 16 h / 0 - 20 °C

8.1: Et₃N / CH₂Cl₂ / 1 h / -10 °C

9.1: TBAF / tetrahydrofuran / 1 h / 0 - 5 °C

9.2: 812 mg / aq. NaOH / tetrahydrofuran / 0.75 h / 0 - 5 °C

10.1: n-BuLi; BF₃*Et₂O / tetrahydrofuran; hexane / 1.5 h / -78 °C

10.2: aq. TFA / 3 h / 20 °C

10.3: 88 percent / DBU / CH₂Cl₂ / 0.5 h / 0 - 5 °C

11.1: 100 percent / magnesium monoperoxophthalate hexahydrate / ethanol / 1.5 h / 20 °C

12.1: DIBALH / CH₂Cl₂ / 1 h / -78 °C

13.1: 1.107 g / PPTS / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; copper(l) iodide; lithium borohydride; n-butyllithium; copper diacetate; magnesium bis(monoperoxyphthalate)hexahydrate; tributylphosphine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; zinc; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; toluene;
DOI:10.1021/jo026743f

Reference yield:

: 63952-83-0
(2S)-acetic acid 6-oxo-3,6-dihydro-2H-pyran-2-ylmethyl ester

: 527742-75-2
[2R,6S]-2-[(2R)-4-benzenesulfonyl-2-methylbutyl]-6-ethoxy-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 11 steps

1.1: 96 percent / 2N HCl / 16 h / 20 °C

2.1: 89 percent / imidazole; DMAP / CH₂Cl₂; toluene / 16 h / 0 - 20 °C

3.1: CuI / 0 °C

3.2: 84 percent / diethyl ether / 1 h / 0 °C

4.1: 98 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

5.1: 83 percent / Bu₃P / tetrahydrofuran / 16 h / 0 - 20 °C

6.1: Et₃N / CH₂Cl₂ / 1 h / -10 °C

7.1: TBAF / tetrahydrofuran / 1 h / 0 - 5 °C

7.2: 812 mg / aq. NaOH / tetrahydrofuran / 0.75 h / 0 - 5 °C

8.1: n-BuLi; BF₃*Et₂O / tetrahydrofuran; hexane / 1.5 h / -78 °C

8.2: aq. TFA / 3 h / 20 °C

8.3: 88 percent / DBU / CH₂Cl₂ / 0.5 h / 0 - 5 °C

9.1: 100 percent / magnesium monoperoxophthalate hexahydrate / ethanol / 1.5 h / 20 °C

10.1: DIBALH / CH₂Cl₂ / 1 h / -78 °C

11.1: 1.107 g / PPTS / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; copper(l) iodide; lithium borohydride; n-butyllithium; magnesium bis(monoperoxyphthalate)hexahydrate; tributylphosphine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene;
DOI:10.1021/jo026743f