7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Base Information

Chemical Name:7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine
CAS No.:1312291-26-1
Molecular Formula:C₂₅H₃₂ClN₅O
Molecular Weight:454.015
Hs Code.:

Synonyms:7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Suppliers and Price of 7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

There total 5 articles about 7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1312291-23-8
{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

: 142-25-6
N,N',N'-trimethylenediamine

: 1312291-26-1
7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Guidance literature:: {5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride; With thionyl chloride; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 3h;

N,N',N'-trimethylenediamine; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 2h;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water;

Reference yield:

: 300665-25-2
(2-morpholin-4-yl-5-nitrophenyl)methanol

: 1312291-26-1
7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 20 °C

2.1: pentan-1-ol / 3 h / Reflux

3.1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 3 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With thionyl chloride; ammonium formate; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; pentan-1-ol;

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 1312291-26-1
7-chloro-N-[3-({[2-(dimethylamino)ethyl](methyl)amino}methyl)-4-(morpholin-4-yl)phenyl]quinolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / 3 h / 0 °C

2.1: 1 h / 115 °C

3.1: ammonium formate / palladium 10% on activated carbon / ethanol / 1 h / 20 °C

4.1: pentan-1-ol / 3 h / Reflux

5.1: thionyl chloride / 1-methyl-pyrrolidin-2-one / 3 h / 0 - 20 °C

5.2: 2 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; thionyl chloride; ammonium formate; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; pentan-1-ol;