2-(4-Methoxyphenyl)cyclohexanone

Base Information

Chemical Name:2-(4-Methoxyphenyl)cyclohexanone
CAS No.:37087-68-6
Molecular Formula:C₁₃H₁₆O₂
Molecular Weight:204.269
Hs Code.:
NSC Number:78469
DSSTox Substance ID:DTXSID30291823
Nikkaji Number:J836.563F
Mol file:37087-68-6.mol

Synonyms:2-(4-methoxyphenyl)cyclohexanone;37087-68-6;2-(4-methoxyphenyl)cyclohexan-1-one;2-(4-METHOXYPHENYL)-1-CYCLOHEXANONE;NSC78469;SCHEMBL318066;DTXSID30291823;BEBTXYAQBNBPJY-UHFFFAOYSA-N;2-(4-Methoxyphenyl)-cyclohexanone;NSC-78469;AKOS011898125;2-(4-methoxyphenyl)-cyclohexan-1-one;EN300-1153059

Suppliers and Price of 2-(4-Methoxyphenyl)cyclohexanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-(4-Methoxyphenyl)cyclohexanone

Chemical Property:

Vapor Pressure:0.000118mmHg at 25°C
Boiling Point:335.7°Cat760mmHg
Flash Point:149.9°C
PSA：26.30000
Density:1.068g/cm³
LogP:2.92190
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:204.115029749
Heavy Atom Count:15
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2CCCCC2=O
Uses 2-(4-Methoxyphenyl)cyclohexanone is a useful synthetic intermediate in the synthesis of rac-14-epi-Dextromethorphan (D299440); an analog of Dextromethorphan (D299445) which is an antitussive compound showing analgesic properties. Dextromethorphan is used in cough medication formulations.

Technology Process of 2-(4-Methoxyphenyl)cyclohexanone

There total 47 articles about 2-(4-Methoxyphenyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: allyl 1-(4-methoxyphenyl)-2-oxocyclohexanecarboxylate

: 37087-68-6,167476-39-3
2-(4-methoxyphenyl)cyclohexanone

Guidance literature:: With formic acid; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In 1,4-dioxane; at 40 ℃; for 10h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jo5014806

Reference yield: 95.0%

: 1-(4-methoxyphenyl)cyclohexane-1,2-diol

: 37087-68-6,167476-39-3
2-(4-methoxyphenyl)cyclohexanone

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.7b01679

Reference yield: 93.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 37087-68-6,167476-39-3
2-(4-methoxyphenyl)cyclohexanone

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; Bu₃SnF; tri-tert-butyl phosphine; In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/ja204331w