1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

Base Information

Chemical Name:1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one
CAS No.:1202757-57-0
Molecular Formula:C₂₁H₁₇ClFN₅O₂
Molecular Weight:425.85
Hs Code.:

Synonyms:1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

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Chemical Property of 1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

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Technology Process of 1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

There total 4 articles about 1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202759-98-5
C₁₈H₁₅ClFN₅O

: 814-68-6,25189-84-8
acryloyl chloride

: 1202757-57-0
1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

Guidance literature:: C₁₈H₁₅ClFN₅O; acryloyl chloride; In tetrahydrofuran; at -10 ℃;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.166667h;

Reference yield:

: 575482-92-7
C₁₀H₆Cl₂FN₃

: 1202757-57-0
1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tert-Amyl alcohol / 12 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 0 °C

3.1: tetrahydrofuran / -10 °C

3.2: 0.17 h

With trifluoroacetic acid; acetic acid; In tetrahydrofuran; tert-Amyl alcohol; dichloromethane;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1202757-57-0
1-(6-(4-(3-chlorophenylamino)-5-fluoropyrimidin-2-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2.1: acetic acid / tert-Amyl alcohol / 12 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: 0 °C

4.1: tetrahydrofuran / -10 °C

4.2: 0.17 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; acetic acid; In tetrahydrofuran; tert-Amyl alcohol; dichloromethane;