(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Base Information

Chemical Name:(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid
CAS No.:1202576-60-0
Molecular Formula:C₂₁H₂₂F₂O₄
Molecular Weight:376.4
Hs Code.:

Synonyms:(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

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Chemical Property of (3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

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Technology Process of (3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

There total 12 articles about (3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1202578-07-1
(3S)-3-(4-{[(1R)-4-(Difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

: 1202576-60-0
(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In water; acetonitrile; at 0 - 20 ℃; Phosphate buffer;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1202576-60-0
(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; formic acid / Noyori's catalyst / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0 °C

2.2: 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

4.1: dichloromethane; ethanol / 20 °C

5.1: ethanol / 2 h / Heating

5.2: 20 °C

6.1: triphenylphosphine; ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate / tetrahydrofuran / 20 - 50 °C / Inert atmosphere

6.2: 0 °C / Inert atmosphere

7.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile; water / 0 - 20 °C / Phosphate buffer

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; n-butyllithium; formic acid; ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate; sodium hydride; triethylamine; triphenylphosphine; Noyori's catalyst; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 1202576-60-0
(3S)-3-(4-{[(1R)-4-(difluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; formic acid / 0 - 35 °C / Inert atmosphere

1.2: 2 h / 35 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

6.1: triphenylphosphine; ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate / tetrahydrofuran / 20 - 50 °C / Inert atmosphere

6.2: 0 °C / Inert atmosphere

7.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile; water / 0 - 20 °C / Phosphate buffer

With 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; lithium aluminium tetrahydride; formic acid; ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate; hydrogen; sodium hydride; triethylamine; triphenylphosphine; Raney nickel; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;