(R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

Base Information

• Chemical Name: (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester
• CAS No.: 1206634-55-0
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 1206634-55-0.mol

Synonyms:(R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

Chemical Property of (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

There total 4 articles about (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.5%

C13H23N3O3 (1206634-54-9) → (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester (1206634-55-0)

Guidance literature:

With hydrogenchloride; In cyclohexane; water; at 20 ℃;

Reference yield:

[2-Ethyl-cyclohex-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine (73739-22-7,73739-27-2,91524-48-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester (1206634-55-0) + (+)-(S)-1-Ethyl-2-oxocyclohexane-1-propanoic acid methyl ester (115867-85-1)

Guidance literature:

[2-Ethyl-cyclohex-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine; acrylic acid methyl ester; With hydroquinone; at 65 ℃; for 48h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 3h; optical yield given as %ee;

Reference yield:

C16H23N + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester (1206634-55-0)

Guidance literature:

C₁₆H₂₃N; acrylic acid methyl ester; at 20 ℃; for 168h; Inert atmosphere;

With acetic acid; In methanol; water; for 3h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/ol300735g

upstream raw materials:

C₁₃H₂₃N₃O₃

[2-Ethyl-cyclohex-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine

acrylic acid methyl ester

2-ethylcyclohexanone

Downstream raw materials:

(R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

C₂₅H₃₀N₂O₃

(R)-(+)-1-benzyloxycarbonyl-4a-ethyl-2,3,4,4a,5,6-hyxahydroazepino[4,3,2-hi]benz[b]indolizin-7(1H)-one