(R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

Base Information

• Chemical Name: (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester
• CAS No.: 1206634-66-3
• Molecular Formula: C₁₂H₁₈O₃
• Molecular Weight: 210.273
• Mol file: 1206634-66-3.mol

Synonyms:(R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

Chemical Property of (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester

There total 4 articles about (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester (1206634-55-0) → (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester (1206634-66-3)

Guidance literature:

With palladium(II) trifluoroacetate; oxygen; acetic acid; dimethyl sulfoxide; at 80 ℃; under 760.051 Torr;

DOI:10.1021/ja206575j

Reference yield:

C16H23N → (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester (1206634-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 168 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 46 h / 100 °C / Inert atmosphere

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; 2,6-dimethylpyridine / 96 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In N,N-dimethyl-formamide;

DOI:10.1002/anie.201303067

Reference yield:

C15H28O3Si → (R)-(-)-1-ethyl-2-oxo-3-cyclohexene-1-propionic acid methyl ester (1206634-66-3)

Guidance literature:

With 2,6-dimethylpyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1002/anie.201303067

upstream raw materials:

(R)-(-)-1-ethyl-2-oxocyclohexane-1-propanoic acid methyl ester

2-ethylcyclohexanone

Downstream raw materials:

(R)-3-(1-(2-aminophenyl)-8-ethyl-5,6,7,8-tetrahydroindolizin-8-yl)propanoic acid