(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester
CAS No.:1394049-80-9
Molecular Formula:C₃₂H₃₇N₅O₈
Molecular Weight:619.674
Hs Code.:

(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

Synonyms:(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

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Chemical Property of (2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

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Technology Process of (2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

There total 3 articles about (2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1394049-42-3
(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

: 1394049-80-9
(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

Guidance literature:: t-Boc-L-valine; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 0.25h; Inert atmosphere;

(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1383026-42-3
[(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester

: 1394049-80-9
(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C / Inert atmosphere

2.1: samarium diiodide / water; tetrahydrofuran / 0.25 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; acetonitrile / Inert atmosphere

4.1: HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

4.2: 0.25 h / Inert atmosphere

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.17 h / Inert atmosphere

5.2: 2 h / Inert atmosphere

6.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.25 h / Inert atmosphere

6.2: 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; samarium diiodide; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1394050-22-6
[(R)-1-(biphenyl-4-yl)-methyl-2-(2,2,5-trimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-ethyl]-carbamic acid t-butyl ester

: 1394049-80-9
(2S,4R)-2-((S)-2-amino-3-methylbutyryloxymethyl)-5-biphenyl-4-yl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid 5-methyl-2-oxo[1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: samarium diiodide / water; tetrahydrofuran / 0.25 h / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; acetonitrile / Inert atmosphere

3.1: HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 0.25 h / Inert atmosphere

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.17 h / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.25 h / Inert atmosphere

5.2: 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; samarium diiodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;