(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester
CAS No.:1394049-42-3
Molecular Formula:C₂₇H₂₈N₄O₇
Molecular Weight:520.542
Hs Code.:

Synonyms:(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Chemical Property of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

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Technology Process of (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

There total 17 articles about (2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394050-32-8
(2S,4R)-5-biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[((1-trityl)-1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester

: 1394049-42-3
(2S,4R)-5-(biphenyl-4-yl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl ester

Guidance literature:: With hydrogenchloride; methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1394049-40-1
(2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

: 1394049-42-3
(2S,4R)-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl ester

Guidance literature:: (2S,4R)-5-Biphenyl-4-yl-2-hydroxymethyl-2-methyl-4-[(3H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 0.166667h; Inert atmosphere;

4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; With 4-methyl-morpholine; In dichloromethane; for 2h; Inert atmosphere;

Reference yield:

: 1394050-43-1
(2S,4R)-4-amino-5-biphenyl-4-yl-2-(hydroxymethyl)-2-methylpentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)methyl ester

: 1394049-42-3
(2S,4R)-5-(biphenyl-4-yl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)-amino]-pentanoic acid (5-methyl-2-oxo-[1,3]dioxol-4-yl)-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 18 h / 0 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere; Industry scale

2.2: 0.5 h / 0 °C / Inert atmosphere

3.1: hydrogenchloride; methanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;