4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

Base Information

Chemical Name:4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide
CAS No.:1415242-44-2
Molecular Formula:C₂₄H₂₂Cl₂F₃N₃O₃
Molecular Weight:528.358
Hs Code.:

Synonyms:4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

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Chemical Property of 4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

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Technology Process of 4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

There total 4 articles about 4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1013920-76-7
4-amino-2-ethylisoxazolidin-3-one

: 1352242-58-0
4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid

: 1415242-44-2
4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

Guidance literature:: 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

4-amino-2-ethylisoxazolidin-3-one; With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1352242-56-8
4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

: 1415242-44-2
4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 4.5 h / 20 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / 20 °C

2.2: 20 °C / Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1352242-81-9
4-[(R)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-nitromethyl-butyryl]-2-methyl-benzoic acid tert-butyl ester

: 1415242-44-2
4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; zinc / N,N-dimethyl-formamide; water / 2 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 4.5 h / 20 °C

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1 h / 20 °C

3.2: 20 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; trifluoroacetic acid; zinc; In dichloromethane; water; N,N-dimethyl-formamide;