4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester
• CAS No.: 1352242-56-8
• Molecular Formula: C₂₃H₂₂Cl₂F₃NO₂
• Molecular Weight: 472.334

Synonyms:4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

Chemical Property of 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

There total 4 articles about 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-[(R)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-nitromethyl-butyryl]-2-methyl-benzoic acid tert-butyl ester (1352242-81-9) → 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester (1352242-56-8)

Guidance literature:

With hydrogenchloride; zinc; In water; N,N-dimethyl-formamide; at 80 ℃; for 2h; Product distribution / selectivity;

Reference yield: 16.0%

4-[(R)-4-(3,5-dichloro-phenyl)-1-oxy-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester (1352242-57-9) → 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester (1352242-56-8)

Guidance literature:

With hydrogenchloride; titanium(III) chloride; sodium acetate; In tetrahydrofuran; water; for 18h;

Reference yield:

4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester (1352242-83-1) → 4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester (1352242-56-8)

Guidance literature:

With hydrogen; Raney Nickel; In ethanol; water; at 20 ℃; under 760.051 Torr; Inert atmosphere;

upstream raw materials:

4-[(3R)-3-cyano-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-butyryl]-2-methylbenzoic acid tert-butyl ester

4-[(R)-4-(3,5-dichloro-phenyl)-1-oxy-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid tert-butyl ester

4-[(R)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-3-nitromethyl-butyryl]-2-methyl-benzoic acid tert-butyl ester

4-[(E)-3-(3,5-dichloro-phenyl)-4,4,4-trifluoro-but-2-enoyl]-2-methyl-benzoic acid tert-butyl ester

Downstream raw materials:

4-[(R)-4-(3,5-dichloro-phenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-2-methyl-benzoic acid

C₂₂H₁₉Cl₂F₃N₂OS

4-[(3R)-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-2,4-dihydropyrrol-5-yl]-N-(1,1-dioxothietan-3-yl)-2-methyl-benzamide

4-[(R)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]-N-((R)-2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide

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