N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane

Base Information

• Chemical Name: N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane
• CAS No.: 277760-12-0
• Molecular Formula: C₄₇H₆₈N₄O₈S₄
• Molecular Weight: 945.343

Synonyms:N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane

Chemical Property of N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane

Chemical Property:

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Technology Process of N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane

There total 4 articles about N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl bromide (74-96-4) + N1,N5,N13,N17-tetra(p-toluenesulfonyl)-1,17-diamino-5,13-diazaheptadecane (143944-96-1) → N1,N5,N13,N17-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane (277760-12-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1016/S0968-0896(00)00156-5

Reference yield:

N1,N7-di(p-toluenesulfonyl)-1,7-diaminoheptane (81505-98-8) → N1,N5,N13,N17-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane (277760-12-0)

Guidance literature:

Multi-step reaction with 4 steps

2.1: N₂H₄ / dimethylformamide / 24 h / 70 °C

3.1: 1.2 M HCl / 1 h / 70 °C

3.2: Et₃N / pyridine / 4 h / 20 °C

4.1: 89 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

With hydrogenchloride; potassium carbonate; hydrazine; In N,N-dimethyl-formamide; 1.1: Alkylation / 2.1: Reduction / 3.1: decarbonylation / 3.2: Tosylation / 4.1: Alkylation;

DOI:10.1016/S0968-0896(00)00156-5

Reference yield:

C31H48N4O6S2 (278807-22-0) → N1,N5,N13,N17-tetra(p-toluenesulfonyl)-1,17-bis(ethylamino)-5,13-diazaheptadecane (277760-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1.2 M HCl / 1 h / 70 °C

1.2: Et₃N / pyridine / 4 h / 20 °C

2.1: 89 percent / K₂CO₃ / dimethylformamide / 72 h / 20 °C

With hydrogenchloride; potassium carbonate; In N,N-dimethyl-formamide; 1.1: decarbonylation / 1.2: Tosylation / 2.1: Alkylation;

DOI:10.1016/S0968-0896(00)00156-5

upstream raw materials:

ethyl bromide

N¹,N⁵,N¹³,N¹⁷-tetra(p-toluenesulfonyl)-1,17-diamino-5,13-diazaheptadecane

N¹,N⁷-di(p-toluenesulfonyl)-1,7-diaminoheptane

C₃₁H₄₈N₄O₆S₂

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