Technology Process of 10-amino-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide
There total 8 articles about 10-amino-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 18h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 22.5 h / 0 - 20 °C / Inert atmosphere
2.1: pyridine; thionyl chloride / chloroform / 1.5 h / Reflux
3.1: hydrogenchloride / water; tetrahydrofuran / 24 h / 20 °C
4.1: ammonium hydroxide / water; tetrahydrofuran / 72 h / 20 °C
4.2: 16 h / 0 - 20 °C
5.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux
6.1: water / 24 h / 20 °C
7.1: 125 °C
8.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
9.1: ethanol / 18 h / 90 °C
10.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h
With
pyridine; hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2020.115541
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ammonium hydroxide / water; tetrahydrofuran / 72 h / 20 °C
1.2: 16 h / 0 - 20 °C
2.1: hydroxylamine / water; tetrahydrofuran / 5 h / Reflux
3.1: water / 24 h / 20 °C
4.1: 125 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C
6.1: ethanol / 18 h / 90 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h
With
ammonium hydroxide; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2020.115541
![benzyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)carbamate](/Databaselist/images/loading.webp)
