1072-95-3

Basic information

• Product Name: Cyclohexane, (chloroMethyl)-
• Synonyms: Cyclohexane, (chloroMethyl)-
• CAS NO: 1072-95-3
• Molecular Formula: C₇H₁₃Cl
• Molecular Weight: 132.63112
• Mol File: 1072-95-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 170.2°C at 760 mmHg
• Flash Point: 52°C
• Appearance: /
• Density: 0.954g/cm³
• Vapor Pressure: 1.97mmHg at 25°C
• Refractive Index: 1.448
• CAS DataBase Reference: Cyclohexane, (chloroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexane, (chloroMethyl)-(1072-95-3)
• EPA Substance Registry System: Cyclohexane, (chloroMethyl)-(1072-95-3)

Safety Data

• Hazardous Substances Data: 1072-95-3(Hazardous Substances Data)

Usage

General Description

Cyclohexane, (chloromethyl)-, also known as chloromethyl cyclohexane, is a chemical compound whose molecular formula is C7H13Cl. This colorless, oily liquid is used as an intermediate in the production of various chemicals, including rubber processing chemicals and pharmaceuticals. It has low water solubility and a relatively high boiling point. Its vapor can cause irritation to the eyes, skin, and respiratory system. Continuous exposure may cause kidney or liver damage. Extreme caution should be used while handling, and it should be stored in a cool, dry, well-ventilated area away from heat and ignition sources.

Upstream product

• 100-49-2 cyclohexylmethyl alcohol 
• 6099-86-1 cyclohexylmethyl chlorocarbonate 
• 67-66-3 chloroform 
• 110-83-8 cyclohexene 
• 956465-10-4 5,5-dihydro-5-[(methanesulfonyl)imino]dibenzothiophene 
• 75-09-2 dichloromethane 
• 110-82-7 cyclohexane 
• 71996-32-2 N-(5λ⁴-dibenzo[b,d]thiophen-5-ylidene)-4-methylbenzenesulfonamide 
• 87100-31-0 2-(chloro(cyclohexyl)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 1188429-04-0 8-(chloromethyl)-1,4-dioxaspiro[4.5]decane 
• 23521-81-5 (1,4-dioxaspiro[4.5]dec-8-yl)methanol 
• 542-18-7 cyclohexyl chloride 
• 7639-12-5 trans-1-hydroxymethyl-2-chlorocyclohexane 

Downstream Products

• 106275-80-3 3-(2-cyclohexylethyl)pyridine 
• 29805-59-2 diethyl (cyclohexylmethyl)propanedioate 
• 18081-22-6 <(Trimethylsilyl)methyl>cyclohexane 
• 90754-63-5 2-(4-Cyclohexylmethyl-piperazin-1-yl)-ethanol 
• 4435-14-7 2-cyclohexylacetonitrile 
• 134425-22-2 3-n-butyl-4-[(2'-cyanobiphenyl-4-yl)methyl]-5-(cyclohexylmethylthio)-4H-1,2,4-triazole 
• 82166-21-0 methyl cyclohexane 
• 101121-31-7 3-Cyclohexyl-2-<4-(2-diaethylamino-aethoxy)-phenyl>-2-p-tolyl-propionsaeurenitril 
• 201286-78-4 methyl 1-cyclohexylmethyl-3-methyl-1 H-indole-6-carboxylate 
• 5292-21-7 Cyclohexylacetic acid 
• 148703-18-8 1-(cyclohexylmethyl)piperidine-4-carboxamide 
• 1188429-05-1 benzyl 4-(chloromethyl)-1-cyanocyclohexylcarbamate 

Relevant articles and documents

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Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors

The design, synthesis and structure-activity relationships associated with a series of bridged tricyclic pyrimidinone carboxamides as potent inhibitors of HIV-1 integrase strand transfer are described. Structural modifications to these molecules were made in order to examine the effect on potency towards wild-type and clinically-relevant resistant viruses. The [3.2.2]-bridged tricyclic system was identified as an advantageous chemotype, with representatives exhibiting excellent antiviral activity against both wild-type viruses and the G140S/Q148H resistant virus that arises in response to therapy with raltegravir and elvitegravir.

HOMOLOGATION DES DERIVES HALOGENES

The halide R-X is converted, in two steps, to its homologous R-CH2-X.