N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
CAS No.:1195769-46-0
Molecular Formula:C₂₅H₂₁F₃N₄O₂S₂
Molecular Weight:530.595
Hs Code.:

Synonyms:N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

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Chemical Property of N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

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Technology Process of N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

There total 11 articles about N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1195768-23-0
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: potassium vinyltrifluoroborate

: 1195769-46-0
N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In propan-1-ol; at 100 ℃;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195769-46-0
N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: pyridine / dichloromethane / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

5.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

5.2: 20 - 80 °C

6.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 100 °C

With pyridine; N-Bromosuccinimide; caesium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; propan-1-ol; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester

: 1195769-46-0
N-{3-[2-(1,1-dimethylethyl)-5-(2-ethenyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / nickel / tetrahydrofuran; methanol; water / 70 °C

2.1: pyridine / dichloromethane / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

4.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

4.2: 20 - 80 °C

5.1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / propan-1-ol / 100 °C

With pyridine; N-Bromosuccinimide; hydrazine hydrate; triethylamine; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; nickel; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; N,N-dimethyl acetamide; water;