5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

Base Information

Chemical Name:5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline
CAS No.:1394124-75-4
Molecular Formula:C₂₅H₂₀FN₃OS
Molecular Weight:429.518
Hs Code.:

Synonyms:5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

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Chemical Property of 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

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Technology Process of 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

There total 3 articles about 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1394124-69-6
3-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-1-(4-fluorophenyl)prop-2-en-1-one

: 1394124-75-4
5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

Guidance literature:: With cetyltrimethylammonium bromide; hydrazine hydrate; In water; at 80 ℃; for 0.5h;
DOI:10.5012/bkcs.2012.33.6.2012

Reference yield:

: 4771-31-7
2-phenyl-4-chloromethylthiazole

: 1394124-75-4
5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: potassium hydroxide / ethanol / 6 h / 20 °C

3: cetyltrimethylammonium bromide; hydrazine hydrate / water / 0.5 h / 80 °C

With cetyltrimethylammonium bromide; potassium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 2: Claisen Schmidt condensation;
DOI:10.5012/bkcs.2012.33.6.2012

Reference yield:

: 103789-67-9
4-((2-phenylthiazol-4-yl)methoxy)benzaldehyde

: 1394124-75-4
5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 6 h / 20 °C

2: cetyltrimethylammonium bromide; hydrazine hydrate / water / 0.5 h / 80 °C

With cetyltrimethylammonium bromide; hydrazine hydrate; potassium hydroxide; In ethanol; water; 1: Claisen Schmidt condensation;
DOI:10.5012/bkcs.2012.33.6.2012