103789-67-9

Upstream product

• 4771-31-7 2-phenyl-4-chloromethylthiazole 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 173191-93-0 4-(2-Phenyl-thiazol-4-ylmethoxy)-benzaldehyde oxime 
• 173191-94-1 N-[4-(2-Phenyl-thiazol-4-ylmethoxy)-benzyl]-hydroxylamine 
• 1394124-69-6 3-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-1-(4-fluorophenyl)prop-2-en-1-one 
• 1394124-70-9 C₂₅H₁₈BrNO₂S 
• 1394124-72-1 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-phenylpyrazoline 
• 1394124-73-2 C₂₆H₂₃N₃OS 
• 1394124-74-3 C₂₆H₂₃N₃O₂S 
• 1394124-75-4 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-fluorophenyl)pyrazoline 
• 1394124-76-5 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-bromophenyl)pyrazoline 
• 1394124-77-6 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-(4-nitrophenyl)pyrazoline 
• 1394124-78-7 5-(4-((2-phenylthiazol-4-yl)methoxyphenyl))-3-phenyl-2-isoxazoline 
• 1394124-79-8 C₂₆H₂₂N₂O₂S 
• 1394124-80-1 C₂₆H₂₂N₂O₃S 
• 1394124-81-2 C₂₅H₁₉FN₂O₂S 

Relevant academic research and scientific papers

Tromethamine organocatalyzed efficient tandem-multicomponent synthesis of new thiazolyl-4-thiazolidinones in aqueous medium

The catalytic potential of tris(hydroxymethyl)aminomethane (Tromethamine) has been assessed for the one pot three component tandem reaction involving a thiazolylmethoxy phenyl/aromatic carboxaldehyde, substituted amines and thioglycolic acid to form new t

Organocatalyzed Domino Synthesis of New Thiazole-Based Decahydroacridine-1,8-diones and Dihydropyrido[2,3-d : 6,5-d′]- dipyrimidines in Water as Antimicrobial Agents

Organopromoter, 2-aminoethanesulfonic acid was used to catalyze the synthesis of a series of structurally intriguing new hybrids thiazolyl acridine-1,8(2H,5H)-diones and dihydropyrido[2,3-d : 6,5-d′]dipyrimidine-2,4,6,8(1H,3H,5H,7H)-tetraones for the firs

An efficient synthesis of new pyrazolines and isoxazolines bearing thiazolyl and etheral pharmacophores

A convenient synthetic route has been developed to synthesize 5-(4-((2-phenylthiazol-4-yl) methoxy)phenyl)-3-(4-sustituted phenyl)pyrazolines (5a-f) and 5-(4-((2-phenylthiazol-4-yl)methoxy)phenyl)-3-(4-substituted phenyl)isoxazolines (6a-f) starting from

Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.

PROCESS FOR PRODUCTION OF PYRAZOLE COMPOUNDS

As a method capable of conveniently producing a pyrazole compound in a high yield, which is useful as a synthetic intermediate for a pharmaceutical agent such as a therapeutic agent for diabetes and the like, a production method of a compound represented

Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones

A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse - the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and ethoxy-linked oxazole 1,2,4-oxadiazolidine-3,5-diones normalized plasma glucose levels at the 100 mg kg-1 oral dose in the db/db diabetic mouse model, and several amongst them reduced the glucose levels at the 20 mg kg-1 oral dose. The most potent compounds in the db/db mouse model were also active in the ob/ob mouse model normalizing the plasma glucose levels at the 20 mg kg-1 oral dose. The trifluoromethoxy analog 32 was the most active compound of the series, reducing significantly the plasma glucose levels at the 5 mg kg-1 oral dose. Oxadiazole-tailed 1,2,4-oxadiazolidine-3,5-diones were also active in both the db/db and ob/ob diabetic mouse models normalizing plasma glucose levels at the 100 mg kg-1 oral dose.

Azole phenoxy hydroxyureas as selective and orally active inhibitors of 5- lipoxygenase

Azole phenoxy hydroxyureas are a new class of 5-lipoxygenase (5-LO) inhibitors. Structure-activity relationship studies have demonstrated that electronegative substituents on the 2-phenyl portion of the oxazole tail increased the ex vivo potency of these

Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents

In the course of further chemical modification of the novel antidiabetic pioglitazone (AD-4833, U-72, 107), a series of 5-[4-(2- or 4- azolylalkoxy)benzyl- or -benzylidene]-2,4-thiazolidinediones was prepared and evaluated for hypoglycemic and hypolipidemic activities in insulin-resistant, genetically obese, and diabetic KKA(y) mice. Replacement of the 2-pyridyl moiety of pioglitazone by a 2- or 4-oxazolyl or a 2- or 4-thiazolyl moiety greatly enhanced in vivo potency. The corresponding 5-benzylidene-type compounds, in which a methine was used as a linker between the benzene ring and the thiazolidinedione ring, also had potent biological activity. Among the compounds synthesized, 5-[4-[2-(5-methyl-2-phenyl-4- oxazolyl)ethoxy]benzyl]-2,4-thiazolidinedione (18) exhibited the most potent activity, more than 100 times that of pioglitazone. The synthesis and structure-activity relationships for this novel series of derivatives are detailed.