4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

Base Information

Chemical Name:4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol
CAS No.:1421854-18-3
Molecular Formula:C₁₈H₁₆F₄O
Molecular Weight:324.318
Hs Code.:

Synonyms:4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

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Chemical Property of 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

Chemical Property:

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Technology Process of 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

There total 11 articles about 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421854-16-1
4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol

: 1421854-18-3
4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

Guidance literature:: With 1-fluoro-2,6-dichloropyridinium triflate; In dichloromethane; at 20 ℃;

Reference yield:

: 1421854-30-9
4-(4-(benzyloxy)phenyl)-4-(2-fluorophenyl)cyclohex-2-enone

: 1421854-18-3
4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C

3.2: 20 °C

4.1: 1-fluoro-2,6-dichloropyridinium triflate / dichloromethane / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; 1-fluoro-2,6-dichloropyridinium triflate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1421854-31-0
4-(2-fluorophenyl)-4-(4-hydroxyphenyl)cyclohexanone

: 1421854-18-3
4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C

2.2: 20 °C

3.1: 1-fluoro-2,6-dichloropyridinium triflate / dichloromethane / 20 °C

With 1H-imidazole; 1-fluoro-2,6-dichloropyridinium triflate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; N,N-dimethyl-formamide;