1421854-16-1

Basic information

• Product Name: 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol
• Synonyms: 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol
• CAS NO: 1421854-16-1
• Molecular Weight: 306.328
• Mol File: 1421854-16-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol(1421854-16-1)
• EPA Substance Registry System: 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol(1421854-16-1)

Safety Data

• Hazardous Substances Data: 1421854-16-1(Hazardous Substances Data)

Usage

Description

4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol is a complex organic compound characterized by its unique molecular structure, which features a phenol group attached to a cyclohexyl ring with multiple fluorine substitutions. This structure endows the compound with specific properties that make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol is used as a selective estrogen receptor β (ERβ) agonist for its potential therapeutic effects on cognitive deficits and amyloid-β levels. This application is particularly relevant in the context of Alzheimer's Disease, where the compound has demonstrated the ability to moderate cognitive impairments and reduce amyloid-β accumulation in a mouse model.
Additionally, 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol exhibits gender-specific neuroprotective properties in a Parkinson's disease rat model, suggesting its potential utility in the development of targeted therapies for neurodegenerative disorders.

Upstream product

• 1421854-32-1 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone 
• 1421854-34-3 AD-033-2 
• 108-95-2 phenol 
• 1227068-83-8 trifluoromethane sulfonic acid 4,4-difluorocyclohex-1-en-1-yl ester 
• 22515-18-0 4,4-difluorocyclohexanone 
• 101969-75-9 (2-fluorophenyl)(4-hydroxyphenyl)methanone 
• 1421854-31-0 4-(2-fluorophenyl)-4-(4-hydroxyphenyl)cyclohexanone 
• 1421854-30-9 4-(4-(benzyloxy)phenyl)-4-(2-fluorophenyl)cyclohex-2-enone 
• 1421854-29-6 2-(4-(benzyloxy)phenyl)-2-(2-fluorophenyl)acetaldehyde 
• 1421854-28-5 2-(4-(benzyloxy)phenyl)-2-(2-fluorophenyl)ethanol 
• 1421854-27-4 1-(1-(4-(benzyloxy)phenyl)vinyl)-2-fluorobenzene 
• 1147713-98-1 (4-(benzyloxy)phenyl)(2-fluorophenyl)methanone 

Downstream Products

• 1421854-18-3 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES

The present application relates to a composition comprising a selective androgen modulating compound of formula (I) and selective estrogen receptor β agonist of formula (II). The present application also relates to the use of a selective androgen modulating compound of formula (I) in combination with a selective estrogen receptor β agonist of formula (II) in the treatment or prevention of neurodegenerative diseases or disorders,such as Alzheimer's disease, Huntigton's disease, Parkinson's disease, depression, anxiety, multiple sclerosis, symptoms associated with or caused by multiple sclerosis, and acute or chronic pain.

DIPHENYL SUBSTITUTED CYCLOHEXANE DERIVATIVES, USEFUL AS MODULATORS OF THE ESTROGEN RECEPTORS BETA

Disclosed herein are novel di-aromatic compounds of the general formula (I). Also pharmaceutical compositions comprising the novel compounds and the use of the novel compounds in treatment and prevention of diseases and disorders related to estrogen receptors are disclosed. Furthermore, methods for treating and preventing diseases and disorders related to estrogen receptors by administration of the novel compounds are disclosed.