(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

Base Information

Chemical Name:(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester
CAS No.:205646-51-1
Molecular Formula:C₂₃H₂₀Cl₂N₂O₅
Molecular Weight:475.328
Hs Code.:

Synonyms:(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

Chemical Property:

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Technology Process of (E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

There total 6 articles about (E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179106-27-5
(Z)-2-(3-aminophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid, methyl ester

: 179106-28-6
(Z)-2-(3-aminophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

: 75-36-5
acetyl chloride

: 205646-51-1
(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

: (Z)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 20h;

Reference yield:

: 179106-27-5
(Z)-2-(3-aminophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid, methyl ester

: 75-36-5
acetyl chloride

: 205646-51-1
(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/jm0491849

Reference yield:

: 179106-25-3
(E)-2-(3-Nitrophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl-2)propenoic acid, methyl ester

: 205646-51-1
(E)-2-(3-acetamidophenyl)-3-(2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / SnCl₂*2H₂O / ethyl acetate / 4 h / Heating

2: Et₃N / CH₂Cl₂ / 20 h / 20 °C

With triethylamine; tin(ll) chloride; In dichloromethane; ethyl acetate;
DOI:10.1021/jm0491849