2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester
• CAS No.: 708254-77-7
• Molecular Formula: C₃₇H₅₁NO₃Si
• Molecular Weight: 585.902
• Mol file: 708254-77-7.mol

Synonyms:2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester

Chemical Property of 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid (3R,4S)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-hydroxy-ethyl)-3-hydroxymethyl-hexyl ester (708254-75-5) → 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester (708254-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / I₂; PPh₃; imidazole

2: 98 percent / dioxane / 100 °C

With 1H-imidazole; iodine; triphenylphosphine; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2004.03.085

Reference yield: 99.0%

chloroformic acid ethyl ester (541-41-3) + 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester (708254-77-7) → (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid ethyl ester (708254-78-8)

Guidance literature:

In toluene;

DOI:10.1016/j.tetlet.2004.03.085

Reference yield: 92.0%

2-(trimethylsilyl)-ethoxycarbonyl chloride (20160-60-5) + 2,2-Dimethyl-propionic acid 2-{(3R,4S)-1-benzyl-4-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-piperidin-3-yl}-ethyl ester (708254-77-7) → (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester (865853-20-9)

Guidance literature:

at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.06.171

upstream raw materials:

2,2-Dimethyl-propionic acid (3R,4S)-6-(tert-butyl-diphenyl-silanyloxy)-4-(2-hydroxy-ethyl)-3-hydroxymethyl-hexyl ester

Downstream raw materials:

(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid ethyl ester

(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

(+)-N-benzoylmeroquinene aldehyde

quinindine