benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

Base Information

Chemical Name:benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate
CAS No.:162515-06-2
Molecular Formula:C₂₄H₂₃NO₄S
Molecular Weight:421.517
Hs Code.:

Synonyms:benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

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Chemical Property of benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

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Technology Process of benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

There total 7 articles about benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1439-36-7
1-triphenylphosphoranylidene-2-propanone

: 162514-95-6
diphenylmethyl (2S,3R,5R)-3-formyl-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 162515-06-2
benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

Guidance literature:: With lithium perchlorate; In acetonitrile; at -20 ℃; for 4h;
DOI:10.1021/jm9601967

Reference yield:

: 551-16-6
6-Aminopenicillanic Acid

: 162515-06-2
benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaNO₂, H⁺, KBr, 2.) CH₃CO₃H

2: 90 percent / PBu₃ / methanol / 0.75 h / Ambient temperature

3: 84.2 percent / Heating

4: 1.) AcOAg, 2.) thiourea, pyridine / 1.) CH₂Cl₂, 6 h, 2.) DMF, from 0 deg C to RT

5: 1.) oxalyl chloride, DMSO, 2.) TEA / 1.) CH₂Cl₂, -70 deg C, 3 h, 2.) CH₂Cl₂, from -70 deg C to -10 deg C, 20 min

6: 52 percent / LiClO₄ / acetonitrile / 4 h / -20 °C

With pyridine; peracetic acid; oxalyl dichloride; tributylphosphine; TEA; silver(I) acetate; lithium perchlorate; hydrogen cation; dimethyl sulfoxide; thiourea; potassium bromide; sodium nitrite; In methanol; acetonitrile;
DOI:10.1021/jm9601967

Reference yield:

: 5350-57-2
benzophenone hydrazone

: 162515-06-2
benzhydryl (E)-(2S,3S,5R)-3-methyl-7-oxo-3-(3-oxo-but-1-enyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaNO₂, H⁺, KBr, 2.) CH₃CO₃H

2: 90 percent / PBu₃ / methanol / 0.75 h / Ambient temperature

3: 84.2 percent / Heating

4: 1.) AcOAg, 2.) thiourea, pyridine / 1.) CH₂Cl₂, 6 h, 2.) DMF, from 0 deg C to RT

5: 1.) oxalyl chloride, DMSO, 2.) TEA / 1.) CH₂Cl₂, -70 deg C, 3 h, 2.) CH₂Cl₂, from -70 deg C to -10 deg C, 20 min

6: 52 percent / LiClO₄ / acetonitrile / 4 h / -20 °C

With pyridine; peracetic acid; oxalyl dichloride; tributylphosphine; TEA; silver(I) acetate; lithium perchlorate; hydrogen cation; dimethyl sulfoxide; thiourea; potassium bromide; sodium nitrite; In methanol; acetonitrile;
DOI:10.1021/jm9601967