5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

Base Information

Chemical Name:5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide
CAS No.:1403591-06-9
Molecular Formula:C₂₆H₃₆N₄O₃
Molecular Weight:452.597
Hs Code.:

Synonyms:5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

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Chemical Property of 5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

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Technology Process of 5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

There total 5 articles about 5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403596-15-5
tert-butyl 3-(3-{[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]carbamoyl}-5-[ethyl(oxan-4-yl)amino]-4-methylphenyl)azetidine-1-carboxylate

: 1403591-06-9
5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403591-06-9
5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 64 h

4.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

4.2: 22 h / 20 °C

5.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

5.2: 16 h / 80 °C / Inert atmosphere

6.1: sodium hydroxide / tetrahydrofuran; methanol / 38 h / 20 - 50 °C

6.2: pH 5

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

7.2: 16 h / 20 °C

8.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; iron; sodium carbonate; ammonium chloride; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403591-06-9
5-(azetidin-3-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

2.2: 64 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.08 h / Inert atmosphere

3.2: 22 h / 20 °C

4.1: chloro-trimethyl-silane; zinc; ethylene dibromide / ISOPROPYLAMIDE / Inert atmosphere

4.2: 16 h / 80 °C / Inert atmosphere

5.1: sodium hydroxide / tetrahydrofuran; methanol / 38 h / 20 - 50 °C

5.2: pH 5

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

6.2: 16 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; chloro-trimethyl-silane; iron; ammonium chloride; acetic acid; ethylene dibromide; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;