Technology Process of 3-(4-((3-(2,6-dimethylphenyl)phenyl)methoxy)phenyl)propiolic acid amide
There total 5 articles about 3-(4-((3-(2,6-dimethylphenyl)phenyl)methoxy)phenyl)propiolic acid amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
cooling with ice;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride / 3 h / Reflux
2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C
3: lithium hydroxide monohydrate; water / methanol / 6 h / Reflux
4: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
5: ammonium hydroxide / tetrahydrofuran; water / 20 °C / cooling with ice
With
ammonium hydroxide; thionyl chloride; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; potassium iodide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C
2: lithium hydroxide monohydrate; water / methanol / 6 h / Reflux
3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C
4: ammonium hydroxide / tetrahydrofuran; water / 20 °C / cooling with ice
With
ammonium hydroxide; oxalyl dichloride; lithium hydroxide monohydrate; water; potassium carbonate; potassium iodide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
