7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

Base Information

Chemical Name:7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one
CAS No.:1410840-18-4
Molecular Formula:C₂₅H₂₉BrO₃Si
Molecular Weight:485.493
Hs Code.:

Synonyms:7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

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Chemical Property of 7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

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Technology Process of 7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

There total 5 articles about 7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1410840-12-8
2-(1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclohexa-2,5-dien-1-yl)acetic acid

: 1410840-18-4
7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

Guidance literature:: With 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide; In hexane; chloroform; at -40 ℃; for 1h; regioselective reaction;
DOI:10.1021/ol302908a

Reference yield:

: 1410840-77-5
tert-butyl 1-(2-ethoxy-2-oxoethyl)cyclohexa-2,5-dienecarboxylate

: 1410840-18-4
7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 - 50 °C

5: 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide / hexane; chloroform / 1 h / -40 °C

With 1H-imidazole; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide; triethylamine; methyl chloroformate; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol302908a

Reference yield:

: 68654-50-2
1-Ethoxycarbonylmethyl-1-carboxy-cyclohexadien-(2,5)

: 1410840-18-4
7-bromo-3a-(((tert-butyldiphenylsilyl)oxy)methyl)-3,3a,7,7a-tetrahydrobenzofuran-2(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 - 50 °C

4: 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide / hexane; chloroform / 1 h / -40 °C

With 1H-imidazole; 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; N-Bromosuccinimide; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; hexane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol302908a