5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

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Chemical Name:5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine
CAS No.:1391081-30-3
Molecular Formula:C₂₄H₂₆N₄O₃S
Molecular Weight:450.561
Hs Code.:

Synonyms:5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

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Chemical Property of 5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

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Technology Process of 5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

There total 6 articles about 5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59303-10-5
2-chloro-5-methyl-pyrazine

: 1382136-68-6
5-(4-methanesulfonyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine

: 1391081-30-3
5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 150 ℃; Microwave irardiation;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1391081-30-3
5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 55 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 170 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 50 °C / 3750.38 Torr

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: caesium carbonate / dimethyl sulfoxide / 150 °C / Microwave irardiation

With hydrogen; sodium carbonate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 877133-58-9
6-chloro-4-iodo-pyridin-3-ol

: 1391081-30-3
5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 55 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.17 h / 170 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 50 °C / 3750.38 Torr

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: caesium carbonate / dimethyl sulfoxide / 150 °C / Microwave irardiation

With hydrogen; sodium carbonate; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;