59303-10-5

Basic information

• Product Name: 2-CHLORO-5-METHYLPYRAZINE
• Synonyms: 2-CHLORO-5-METHYLPYRAZINE;C90111;2-Chloro-5-methyl-1,4-diazine;Pyrazine,2-chloro-5-Methyl-
• CAS NO: 59303-10-5
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.5596
• Mol File: 59303-10-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 172℃
• Flash Point: 72℃
• Appearance: /
• Density: 1.234
• Vapor Pressure: 1.798mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.31±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-METHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-METHYLPYRAZINE(59303-10-5)
• EPA Substance Registry System: 2-CHLORO-5-METHYLPYRAZINE(59303-10-5)

Safety Data

• Hazardous Substances Data: 59303-10-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-methylpyrazine is a chemical compound with the molecular formula C5H6ClN2. It is a colorless to pale yellow liquid with a strong, pungent odor. 2-CHLORO-5-METHYLPYRAZINE is commonly used as a flavoring agent in the food and beverage industry, adding a roasted, nutty, and earthy note to various products. It is also utilized as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Chloro-5-methylpyrazine is considered to be relatively stable under normal conditions, but it should be handled with care due to its potential to cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C5H5ClN2/c1-4-2-8-5(6)3-7-4/h2-3H,1H3

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 67-66-3 chloroform 
• 109-08-0 2-Methylpyrazine 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 
• 1433707-33-5 N-[[1-(5-methoxypyrazin-2-yl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide 
• 1400707-76-7 N-cyclopropyl-N-[1-(5-methylpyrazin-2-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide 
• 1391081-30-3 5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine 
• 500370-18-3 2-methyl-5-phenoxypyrazine 

Relevant articles and documents

Production method of 2-methyl-3(5 or 6)-methylthio pyrazine

The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.