59303-10-5

Usage

Uses

Used in Flavoring Industry:
2-Chloro-5-methylpyrazine is used as a flavoring agent in the food and beverage industry, where it imparts a roasted, nutty, and earthy note to a wide range of products. Its unique flavor profile enhances the taste and aroma of various consumables, contributing to a richer sensory experience for consumers.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-chloro-5-methylpyrazine is utilized as a building block in the synthesis of various drugs. Its chemical structure allows for the development of new medicinal compounds, potentially leading to the creation of innovative treatments and therapies.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, 2-chloro-5-methylpyrazine serves as a key component in the synthesis of different agrochemicals. Its incorporation into these products can enhance their effectiveness in agricultural applications, such as pest control and crop protection.

InChI:InChI=1/C5H5ClN2/c1-4-2-8-5(6)3-7-4/h2-3H,1H3

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 67-66-3 chloroform 
• 109-08-0 2-Methylpyrazine 

Downstream Products

• 5521-58-4 5-methylpyrazin-2-amine 
• 500370-18-3 2-methyl-5-phenoxypyrazine 
• 1391081-30-3 5-(4-methanesulfonyl-phenyl)-2-[1-(5-methyl-pyrazin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3c]pyridine 
• 1400707-76-7 N-cyclopropyl-N-[1-(5-methylpyrazin-2-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide 
• 1433707-33-5 N-[[1-(5-methoxypyrazin-2-yl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

Production method of 2-methyl-3(5 or 6)-methylthio pyrazine

The invention discloses a production method of 2-methyl-3(5 or 6)-methylthio pyrazine. The method comprises the following steps: adding solvents dichloroethane and triethylamine into a reaction kettle, sealing the reaction kettle, introducing chlorine to control the pressure in the kettle at 0.02-0.03 MPa, pumping a methylpyrazine solution into the reaction kettle by using a metering pump, controlling the temperature at 45-60 DEG C, reacting, and transferring reaction liquid(containing the chlorine)in the kettle into a dichloroethane turnover tank through filter pressing for recycling after the reaction is finished; dissolving the residual 2-methyl-3(5 or 6)-chloropyrazine hydrochloride solid in the reaction kettle with water, adjusting the neutrality, and layering to obtain a 2-methyl-3(5or 6)-chloropyrazine crude product; and dropwise adding thechloropyrazine crude product is into sodium methyl mercaptide, performing reflux reaction , and after reaction liquid is extracted, adding an aid into an organic phase to generate a hydrochloride for separating the non-pyrazine product from the product to greatly improve the aroma quality of the obtained product. The product grade is improved, and the whole production process is safe and environmentally friendly.

Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base

1-Unsubstituted imidazoles and chloroform at 550 deg C in a flow system give mainly 5-chloropyrimidines, together with 4-chloropyrimidines and chloropyrazines.The effects of methyl substituents on the ratio of products is considered.The liquid-phase reactions of 2-methyl- and 2,4,5-trimethyl-imidazole under conditions in which dichlorocarbene is said to be formed in basic or neutral conditions were studied, and compared with the gas-phase reactions with chloroform.