3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

Base Information

Chemical Name:3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid
CAS No.:1013403-78-5
Molecular Formula:C₁₇H₂₄BFN₂O₅
Molecular Weight:366.197
Hs Code.:

Synonyms:3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

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Chemical Property of 3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

Chemical Property:

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Technology Process of 3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

There total 1 articles about 3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873566-75-7
(3-amino-4-fluoro-phenyl)boronic acid

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1013403-78-5
3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

Guidance literature:: (R)-1-Boc-nipecotic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 20 ℃; for 0.333333h;

(3-amino-4-fluoro-phenyl)boronic acid; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

Reference yield:

: 1012317-17-7
1-[4-chloro-6-(morpholin-4-yl)pyrimidin-2-yl]-2-(difluoromethyl)-1H-benzimidazole

: 1013403-78-5
3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

: 4-{3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenyl}-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

Guidance literature:: With cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; acetonitrile; at 140 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 1012317-17-7
1-[4-chloro-6-(morpholin-4-yl)pyrimidin-2-yl]-2-(difluoromethyl)-1H-benzimidazole

: 1013403-78-5
3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenylboronic acid

: 1013403-36-5
2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 0.5 h / 140 °C / microwave irradiation

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With cesium fluoride; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; acetonitrile;