2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

Base Information

Chemical Name:2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine
CAS No.:1013403-36-5
Molecular Formula:C₂₈H₂₈F₃N₇O₂
Molecular Weight:551.571
Hs Code.:

Synonyms:2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

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Chemical Property of 2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

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Technology Process of 2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

There total 7 articles about 2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenyl}-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine

: 1013403-36-5
2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

Guidance literature:: 4-{3-[(3R)-N-tert-butoxycarbonylpiperidin-3-ylcarbonylamino]-4-fluorophenyl}-2-(2-difluoromethylbenzimidazol-1-yl)-6-morpholinopyrimidine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.333333h;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

Reference yield:

: 52127-83-0
4-(2,6-dichloropyrimidin-4-yl)morpholine

: 1013403-36-5
2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: cesium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 0.5 h / 140 °C / microwave irradiation

3: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With potassium carbonate; cesium fluoride; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 873566-75-7
(3-amino-4-fluoro-phenyl)boronic acid

: 1013403-36-5
2-(2-difluoromethylbenzimidazol-1-yl)-4-{4-fluoro-3-[(3R)-piperidin-3-ylcarbonylamino]phenyl}-6-morpholinopyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 0.33 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: cesium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; acetonitrile / 0.5 h / 140 °C / microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

With N-ethyl-N,N-diisopropylamine; cesium fluoride; HATU; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;