3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Base Information

Chemical Name:3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester
CAS No.:608136-37-4
Molecular Formula:C₂₄H₄₀N₂O₅Si
Molecular Weight:464.678
Hs Code.:

3-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-<i>tert</i>-butyl ester

Synonyms:3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Chemical Property of 3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

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Technology Process of 3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

There total 8 articles about 3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 608136-36-3
C₂₄H₄₂N₂O₆Si

: 608136-37-4
3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/jo034441n

Reference yield:

: 608136-23-8
(S)-5-benzyloxy-1-tert-butyldimethylsilyloxy-2-pentanol

: 608136-37-4
3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 92 percent / DMAP; pyridine / CHCl₃ / 0 - 20 °C

2.1: 95 percent / H₂ / Pd/C / methanol / 0.5 h / 20 °C / 760 Torr

3.1: 100 percent / Dess-Martin periodinane / CHCl₃ / 0 - 20 °C

4.1: methanol / 0 - 20 °C

4.2: 58 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C

5.1: 98 percent / aqueous sodium bicarbonate / CHCl₃ / 1.5 h / 0 °C

6.1: 64 percent / H₂O; K₂CO₃ / methanol / 6 h / 20 °C

7.1: 77 percent / PPh₃; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating

With pyridine; dmap; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; 3.1: Dess-Martin oxidation / 7.1: Mitsunobu reaction;
DOI:10.1021/jo034441n

Reference yield:

: 608136-24-9
(S)-2-acetoxy-5-benzyloxy-1-(tert-butyldimethylsilyloxy)pentane

: 608136-37-4
3-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / H₂ / Pd/C / methanol / 0.5 h / 20 °C / 760 Torr

2.1: 100 percent / Dess-Martin periodinane / CHCl₃ / 0 - 20 °C

3.1: methanol / 0 - 20 °C

3.2: 58 percent / acetic acid; sodium cyanoborohydride / methanol / 0 - 20 °C

4.1: 98 percent / aqueous sodium bicarbonate / CHCl₃ / 1.5 h / 0 °C

5.1: 64 percent / H₂O; K₂CO₃ / methanol / 6 h / 20 °C

6.1: 77 percent / PPh₃; EtOOCN=NCOOEt / tetrahydrofuran / 0.5 h / Heating

With water; hydrogen; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; 2.1: Dess-Martin oxidation / 6.1: Mitsunobu reaction;
DOI:10.1021/jo034441n