N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

Base Information

Chemical Name:N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide
CAS No.:116129-77-2
Molecular Formula:C₃₅H₅₁N₅O₆
Molecular Weight:637.82
Hs Code.:

N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

Synonyms:N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

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Chemical Property of N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

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Technology Process of N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

There total 3 articles about N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 116129-75-0
(E)-2-<(4-morpholinylcarbonyl)methyl>-trans-cinnamic acid

: 104882-47-5
(S)-2-Amino-N-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

: 116129-77-2
N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 0 deg C, 2.5 h; 25 deg C, 12 h;
DOI:10.1021/jm00120a006

Reference yield:

: 116129-86-3
(E)-4-phenyl-3-carbethoxyethylbut-3-enoic acid

: 116129-77-2
N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, 5 min, 2.) 1 h

2: 92 percent / LiOH / H₂O; dioxane / 0.17 h / 0 - 5 °C

3: 40 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; isobutyl chloroformate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006

Reference yield:

: 116129-87-4
ethyl 2-<(4-morpholinylcarbonyl)methyl>-trans-cinnamate

: 116129-77-2
N-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-morpholin-4-yl-4-oxo-2-[1-phenyl-meth-(E)-ylidene]-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / LiOH / H₂O; dioxane / 0.17 h / 0 - 5 °C

2: 40 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

With lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006