Tizanidine hydrochloride

Base Information

• Chemical Name: Tizanidine hydrochloride
• CAS No.: 64461-82-1
• Molecular Formula: C₉H₈ClN₅S*ClH
• Molecular Weight: 290.176
• Hs Code.: 2934990002
• European Community (EC) Number: 630-412-1
• UNII: B53E3NMY5C
• DSSTox Substance ID: DTXSID9046990
• Wikidata: Q27274381
• NCI Thesaurus Code: C47760
• RXCUI: 236460
• ChEMBL ID: CHEMBL1200329
• Mol file: 64461-82-1.mol

Synonyms:5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole;DS 103-282;Sirdalud;tizanidine;tizanidine hydrochloride;tizanidine monohydrochloride;Zanaflex

Chemical Property of Tizanidine hydrochloride

Chemical Property:

• Appearance/Colour: Off-white to pale yellow solid
• Vapor Pressure: 2.51E-06mmHg at 25°C
• Melting Point: 280 °C
• Boiling Point: 391.2 °C at 760 mmHg
• Flash Point: 190.4 °C
• PSA: 90.44000
• LogP: 2.35520
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: ~29 mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 288.9955719
• Heavy Atom Count: 17
• Complexity: 300

Purity/Quality:

98% ^*data from raw suppliers

Tizanidine, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl.Cl
• Recent ClinicalTrials: TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME）
• Recent EU Clinical Trials: A Randomized, Double-Blind, Four Treatment, Four period, Crossover Study, with Placebo, Tizanidine Immediate Release and Diphenhydramine to Study the Effect of Tizanidine Extended Release on Simulated Driving Performance, Cognitive, and Psychomotor Functioning
• Description: As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia. As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.
• Uses: An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,

Technology Process of Tizanidine hydrochloride

There total 21 articles about Tizanidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

tizanidine malonate → tizanidine hydrochloride (64461-82-1,74113-36-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 3h;

Reference yield: 98.1%

tizanidine butanoate → tizanidine hydrochloride (64461-82-1,74113-36-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 8h;

Reference yield: 97.5%

tizanidine glycolate → tizanidine hydrochloride (64461-82-1,74113-36-3)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 6h;

upstream raw materials:

tizanidine

4-amino-5-chloro-2,1,3-benzothiadiazole

1-acetylimidazolidin-2-one

Refernces

• 1、 -. "Preparation method for benzothiadiazole derivative". Paragraph 0012; 0042; 0044-0045; 0047-0048; 0050-0051; 0053. . Retrieved 2019/04/10.
• 2、 -. "Preparation method of novel central skeletal muscle relaxant". Paragraph 0070-0072. . Retrieved 2018/03/24.