Chemical Property of Tizanidin e
Chemical Property:
- Appearance/Colour:Off-white to pale yellow solid
- Vapor Pressure:2.51E-06mmHg at 25°C
- Melting Point:280 °C
- Boiling Point:391.2 °C at 760 mmHg
- Flash Point:190.4 °C
- PSA：90.44000
- LogP:2.35520
- Storage Temp.:Desiccate at RT
- Solubility.:H2O: ~29 mg/mL
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:288.9955719
- Heavy Atom Count:17
- Complexity:300
- Purity/Quality:
-
99%, *data from raw suppliers
Tizanidine, Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn,Xi
- Statements:
22-36/37/38
- Safety Statements:
26-36-37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CN=C(N1)[NH2+]C2=C(C=CC3=NSN=C32)Cl.[Cl-]
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Description
As an adrenergic agonist with muscle relaxant activity, tizanidine hydrochloride belongs to the hydrochloride salt form of tizanidine, which is commonly used in the treatment of spasticity, a condition where muscles in human body spasm, cramp, or become tight induced by a variety of medical problems such as multiple sclerosis, spinal cord injury, Lou Gehrig's disease, spastic diplegia, back pain or certain other injuries to the spine or central nervous system. Besides, as a sleep aid and an anticonvulsant, tizanidine hydrochloride has off-label usage for migraine headaches and is effective for some symptoms of fibromyalgia.
As a short-acting muscle relaxer, the antinociceptive effect of tizanidine hydrochloride functions by blocking excess nerve impulses (pain sensations) of the nerve cells that are sent to the brain and control muscle movement, ultimately resulting in muscle relaxation and spasticity alleviation.
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Uses
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Tizanidine (Zanaflex) is a drug that is used as a muscle relaxant. It is a centrally acting α-2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia,
