Tizanidine

Base Information Edit

Chemical Name:Tizanidine
CAS No.:51322-75-9
Molecular Formula:C9H8ClN5S
Molecular Weight:253.715
Hs Code.:2934999090
European Community (EC) Number:610-648-1
UNII:6AI06C00GW
DSSTox Substance ID:DTXSID9023679
Nikkaji Number:J11.180E
Wikipedia:Tizanidine
Wikidata:Q423538
NCI Thesaurus Code:C61976
RXCUI:57258
Pharos Ligand ID:UVBAZLFK7DQV
Metabolomics Workbench ID:43008
ChEMBL ID:CHEMBL1079
Mol file:51322-75-9.mol

Synonyms:5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole;DS 103-282;Sirdalud;tizanidine;tizanidine hydrochloride;tizanidine monohydrochloride;Zanaflex

Suppliers and Price of Tizanidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Tizanidine 98+%
50mg
$ 57.00

Crysdot
Tizanidine 98+%
100mg
$ 77.00

ApexBio Technology
Tizanidine
50mg
$ 77.00

ApexBio Technology
Tizanidine
500mg
$ 553.00

American Custom Chemicals Corporation
TIZANIDINE 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
TIZANIDINE 95.00%
1G
$ 721.57

AHH
5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3benzothiadiazole-4-aminehydrochloride 98%
5g
$ 456.00

Total 40 raw suppliers

Chemical Property of Tizanidine Edit

Chemical Property:

Appearance/Colour:White Solid
Melting Point:221-223°
Boiling Point:391.2 °C at 760 mmHg
PKA:7.48±0.10(Predicted)
Flash Point:190.4 °C
PSA：90.44000
Density:1.821 g/cm³
LogP:2.35520
Solubility.:H2O: ~29 mg/mL
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:253.0188941
Heavy Atom Count:16
Complexity:300

Purity/Quality:

99.9% ^*data from raw suppliers

Tizanidine 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Autonomic Agents: Muscle Relaxants, Central
Canonical SMILES:C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl
Recent ClinicalTrials:Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder Arthroscopy
Recent EU Clinical Trials:A phase III, multicenter, randomized, parallel groups study to assess the efficacy and safety of 0,5 mg Tizaspray? administered intranasally versus Sirdalud? 2 mg tablets, in patients with acute low back pain
Description Tizanidine is a centrally-acting muscle relaxant useful in the treatment of muscle spasms and a variety of spastic conditions.
Uses Labeled Tizanidine, intended for use as an internal standard for the quantification of Tizanidine by GC- or LC-mass spectrometry. Tizanidine could have therapeutic use as a SARS-CoV-2 main protease inhibitor.
Therapeutic Function Muscle relaxant, Spasmolytic
Clinical Use Tizanidine is a centrally acting adrenergic α2 receptor agonist used to treat chronic muscle spasticity conditions, such as multiple sclerosis.
Drug interactions Potentially hazardous interactions with other drugs Anti-arrhythmics: enhanced muscle relaxant effect with procainamide. Antibacterials: concentration increased by ciprofloxacin - avoid; concentration possibly increased by norfloxacin; concentration possibly reduced by rifampicin. Antidepressants: concentration increased by fluvoxamine - avoid. Antihypertensives: enhanced hypotensive effect. Oral contraceptives: clearance of tizanidine reduced by 50%.

Technology Process of Tizanidine

There total 7 articles about Tizanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%