4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

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Chemical Name:4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester
CAS No.:153170-75-3
Molecular Formula:C₂₀H₂₇NO₄S
Molecular Weight:377.505
Hs Code.:

Synonyms:4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

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Chemical Property of 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

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Technology Process of 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

There total 5 articles about 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 153170-71-9
4-<2-(2-oxo-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid, 2,2-dimethylethyl ester

: 153170-75-3
4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

Guidance literature:: With tetraphosphorus decasulfide; In tetrahydrofuran; at 60 ℃; for 0.5h;

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 153170-75-3
4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / palladium(II) acetate, Na₂CO₃, tetrabutylammonium bromide / dimethylformamide / 72 h / Ambient temperature

2: 85.7 percent / TiCl₄, pyridine / tetrahydrofuran; CCl₄ / 1.) 0-3 deg C, 1 h, 2.) RT, overnight

3: 37 g / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / Ambient temperature

4: 42 percent / H₂ / platinum(IV) oxide / ethanol / 2585.7 Torr

5: 77 percent / P₂S₅ / tetrahydrofuran / 0.5 h / 60 °C

With pyridine; tetraphosphorus decasulfide; tetrabutylammomium bromide; hydrogen; palladium diacetate; titanium tetrachloride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 134372-99-9
3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal

: 153170-75-3
4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85.7 percent / TiCl₄, pyridine / tetrahydrofuran; CCl₄ / 1.) 0-3 deg C, 1 h, 2.) RT, overnight

2: 37 g / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / Ambient temperature

3: 42 percent / H₂ / platinum(IV) oxide / ethanol / 2585.7 Torr

4: 77 percent / P₂S₅ / tetrahydrofuran / 0.5 h / 60 °C

With pyridine; tetraphosphorus decasulfide; hydrogen; titanium tetrachloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; ethanol;