2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

Base Information

Chemical Name:2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester
CAS No.:151723-79-4
Molecular Formula:C₂₁H₂₈O₆
Molecular Weight:376.45
Hs Code.:

Synonyms:2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

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Chemical Property of 2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

Chemical Property:

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Technology Process of 2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

There total 2 articles about 2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.7%

: 134372-99-9
3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal

: 105-53-3
diethyl malonate

: 151723-79-4
2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

Guidance literature:: With pyridine; titanium tetrachloride; In tetrahydrofuran; tetrachloromethane; 1.) 0-3 deg C, 1 h, 2.) RT, overnight;

Reference yield:

: 120363-13-5
tert-butyl 4-iodobenzoate

: 151723-79-4
2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / palladium(II) acetate, Na₂CO₃, tetrabutylammonium bromide / dimethylformamide / 72 h / Ambient temperature

2: 85.7 percent / TiCl₄, pyridine / tetrahydrofuran; CCl₄ / 1.) 0-3 deg C, 1 h, 2.) RT, overnight

With pyridine; tetrabutylammomium bromide; palladium diacetate; titanium tetrachloride; sodium carbonate; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 151723-79-4
2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester

: 126016-78-2
N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 37 g / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / Ambient temperature

2: 42 percent / H₂ / platinum(IV) oxide / ethanol / 2585.7 Torr

3: 54 percent / NaHCO₃ / CHCl₃ / 4 h / Ambient temperature

4: 100 percent / trifluoroacetic acid / 0.03 h

5: 1.) sodium ethoxide / 1.) EtOH, 50 deg C, 20 min, 2.) EtOH, 90 deg C, 10 torr, 90 min

6: 1.) N-methylmorpholine (NMM), chlorodimethoxytriazine, 2.) N-methylmorpholine (NMM) / 1.) DMF, RT, 2 h 30 min, 2.) DMF, overnight

With 4-methyl-morpholine; chloro-dimethoxy-triazine; hydrogen; sodium ethanolate; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; platinum(IV) oxide; In ethanol; chloroform;