diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

Base Information

Chemical Name:diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate
CAS No.:884489-38-7
Molecular Formula:C₂₂H₂₈Cl₂NO₅P
Molecular Weight:488.348
Hs Code.:

Synonyms:diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

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Chemical Property of diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

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Technology Process of diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

There total 9 articles about diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 884489-32-1
[3-benzyloxyamino-1-(3,4-dichlorophenyl)-propyl]-phosphonic acid diethyl ester

: 75-36-5
acetyl chloride

: 884489-38-7
diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

Guidance literature:: With triethylamine; In dichloromethane; cooling;
DOI:10.1002/ejoc.200600202

Reference yield: 85.0%

: 884489-38-7
diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

Guidance literature:

Reference yield:

: 20555-91-3
3,4-dichloroiodobenzene

: 884489-38-7
diethyl 3-(N-(benzyloxy)acetamido)-1-(3,4-dichlorophenyl)propylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1: 58 percent / n-Bu₄NOAc; K₂CO₃; KCl / Pd(OAc)2 / dimethylformamide / 1.5 h / 90 °C

2: 70 percent / 24 h / 100 °C

3: 76 percent / aq. HCl / acetone / 60 - 70 °C

4: 92 percent / pyridine; ethanol / 20 °C

5: 91 percent / sodium cyanoborohydride; conc. hydrochloric acid / methanol / 20 °C

6: 85 percent / Et₃N / CH₂Cl₂ / cooling

With hydrogenchloride; potassium chloride; tetrabutylammonium acetate; sodium cyanoborohydride; potassium carbonate; triethylamine; palladium diacetate; In pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Michael addition;
DOI:10.1002/ejoc.200600202