1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose

Base Information

• Chemical Name: 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose
• CAS No.: 73793-15-4
• Molecular Formula: C₃₂H₃₆O₈Si
• Molecular Weight: 576.719
• Mol file: 73793-15-4.mol

Synonyms:1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose

Chemical Property of 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose

There total 2 articles about 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 1,3,5-tri-O-benzoyl-α-D-ribofuranoside (22224-41-5) → 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose (73793-15-4)

Guidance literature:

With 1,2,4-Triazole; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1021/jo00341a005

Reference yield: 31.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 1,3,5-tri-O-benzoyl-α-D-ribofuranoside (22224-41-5) → 1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose (73793-15-4) + C32H36O8Si (79827-19-3)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1021/jo00341a005

Reference yield: 87.0%

1,3,5-tri-O-benzoyl-2-O-(tert-butyldimethylsilyl)-α-D-ribofuranose (73793-15-4) + 4-hydroxy-5-methylpyrimidin-2(1H)-one (65-71-4) → 3',5'-di-O-benzoyl-2'-O-(tert-butyldimethylsilyl)-5-methyluridine (79816-16-3)

Guidance literature:

With chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 0.333333h; Heating;

DOI:10.1021/jo00341a005

upstream raw materials:

tert-butyldimethylsilyl chloride

1,3,5-tri-O-benzoyl-α-D-ribofuranoside

Downstream raw materials:

N⁴-benzoyl-3',5'-O-dibenzoyl-2'-O-(tert-butyldimethylsilyl)cytidine

3',5'-di-O-benzoyl-2'-O-(tert-butyldimethylsilyl)-5-methyluridine

3',5'-di-O-benzoyl-2'-O-(tert-butyldimethylsilyl)uridine

2'-O-(tert-butyldimethylsilyl)-3'-O-benzoyluridine