[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

Base Information

• Chemical Name: [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester
• CAS No.: 934548-16-0
• Molecular Formula: C₂₉H₃₁Cl₂N₃O₅
• Molecular Weight: 572.488
• Mol file: 934548-16-0.mol

Synonyms:[2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

Chemical Property of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

There total 5 articles about [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

(S)-N-[2(chloromethyloxycarbonylamino)-3-phenylpropanoyl]piperidine (934548-17-1) + diclofenac sodium (15307-79-6) → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester (934548-16-0)

Guidance literature:

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/ardp.200600145

Reference yield:

2-(3-trifluoromethyl-phenylamino)-benzoic acid 1-benzyl-2-oxo-2-piperidin-1-yl-ethylcarbamoyloxymethyl ester → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester (934548-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: human plasma / aq. phosphate buffer / 37 °C / pH 7.4

2: 46 percent / CH₂Cl₂ / -10 - 20 °C

3: 23 percent / tetrabutylammonium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; phosphate buffer; dichloromethane;

DOI:10.1002/ardp.200600145

Reference yield:

(2S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one (102292-89-7) → [2-(2,6-dichloro-phenylamino)-phenyl]-acetic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester (934548-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / CH₂Cl₂ / -10 - 20 °C

2: 23 percent / tetrabutylammonium bromide; Et₃N / tetrahydrofuran / 24 h / 20 °C

With tetrabutylammomium bromide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ardp.200600145

upstream raw materials:

(S)-N-[2(chloromethyloxycarbonylamino)-3-phenylpropanoyl]piperidine

diclofenac sodium

(2S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one

(S)-tert-butyl (1-oxo-3-phenyl-1-(piperidin-1-yl)propan-2-yl)carbamate

Downstream raw materials:

(S)-N-[2-(chloromethyloxycarbonylamino)-3-phenylpropanoyl]-N,N-diethylamine

[2-(2,6-dichloroanilino)phenyl]acetic acid

N-(phenylalanyl)-N,N-diethylamine

Refernces