N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

Base Information

Chemical Name:N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide
CAS No.:1438844-79-1
Molecular Formula:C₂₀H₃₂N₂O₂S
Molecular Weight:364.552
Hs Code.:

Synonyms:N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

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Chemical Property of N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

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Technology Process of N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

There total 5 articles about N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1438844-78-0
(1R,2R,5R)-3-((dimethylamino)methyl)-N,6,6-trimethylbicyclo[3.1.1]heptan-2-amine

: 98-59-9
p-toluenesulfonyl chloride

: 1438844-79-1
N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: With dmap; triethylamine; In chloroform; at 0 ℃; for 9h; Reflux;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 1027343-55-0
(1R,2R,5S,7R)-N-tert-butoxycarbonyl-8,8-dimethyl-3-azatricyclo[5.1.1.0(2,5)]nonan-4-one

: 1438844-79-1
N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether; water / 24 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

3: triethylamine; dmap / chloroform / 9 h / 0 °C / Reflux

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; chloroform; water;
DOI:10.1016/j.tetasy.2013.04.003

Reference yield:

: 23978-82-7
(1S,5R)-6,6-dimethylbicyclo<3.1.1>hept-2-ene

: 1438844-79-1
N-((1R,2R,5R)-3-((dimethylamino)methyl)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)-N,4-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 168 h / 20 °C

2: triethylamine; dmap / tetrahydrofuran / 6 h / 20 °C

3: diethyl ether; water / 24 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

5: triethylamine; dmap / chloroform / 9 h / 0 °C / Reflux

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; chloroform; water;
DOI:10.1016/j.tetasy.2013.04.003