2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione
• CAS No.: 866859-57-6
• Molecular Formula: C₄₆H₄₁N₅O₄S
• Molecular Weight: 759.929
• Mol file: 866859-57-6.mol

Synonyms:2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

Chemical Property of 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

There total 13 articles about 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione (866857-28-5) + 4,4'-dimethoxydiphenylmethyl chloride (7525-23-7) → 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione (866859-57-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 50 ℃; for 2h;

DOI:10.1021/jm061223o

Reference yield:

1-methyl-piperazine (109-01-3) → 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione (866859-57-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 68 percent / K₂CO₃ / methanol / 0 - 20 °C

2: NaH / benzene / 2.5 h / Heating

3: 524 mg / hydrazine monohydrate; HOAc / ethanol / 4 h / Heating

4: 89 percent / PPh₃; Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 120 °C / microwave irradiation

5: 60 percent / Et₃N / tetrahydrofuran / 2 h / 50 °C

With sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene; 4: Sonogashira coupling;

DOI:10.1021/jm061223o

Reference yield:

5-(hydroxymethyl)indan-1-one (760995-53-7) → 2-(3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione (866859-57-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 96 percent / Et₃N / tetrahydrofuran / 0 °C

2: 68 percent / K₂CO₃ / methanol / 0 - 20 °C

3: NaH / benzene / 2.5 h / Heating

4: 524 mg / hydrazine monohydrate; HOAc / ethanol / 4 h / Heating

5: 89 percent / PPh₃; Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 120 °C / microwave irradiation

6: 60 percent / Et₃N / tetrahydrofuran / 2 h / 50 °C

With sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene; 5: Sonogashira coupling;

DOI:10.1021/jm061223o

upstream raw materials:

2-(3-(4-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-ynyl)isoindoline-1,3-dione

4,4'-dimethoxydiphenylmethyl chloride

1-methyl-piperazine

5-(hydroxymethyl)indan-1-one

Downstream raw materials:

3-(4-(1-(bis(4-methoxyphenyl)methyl)-6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)prop-2-yn-1-amine